AN EFFICIENT SYNTHESIS AND EVALUATION OF ANTITUMOR ACTIVITIES OF FUNCTIONALIZED PYRANO2,3-bQUINOLINES

Lin Wei; Zhang Mengye; Wang NingXu WentaoShi Daqing

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AN EFFICIENT SYNTHESIS AND EVALUATION OF ANTITUMOR ACTIVITIES OF FUNCTIONALIZED PYRANO2,3-bQUINOLINES

机译：功能化吡喃并2,3-B喹啉抗肿瘤活性的高效合成和评价

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摘要

An efficient synthesis of novel functionalized pyrano2,3-bquinoline derivatives via a three-component reaction of 2-chloroquinoline-3-carbaldehydes, malononitrile and 1,3-dicarbonyl compounds under microwave irradiation is described. This protocol has the advantages of high efficiency, mild reaction conditions, a one-pot procedure, and convenient operation. All of these compounds were evaluated for their antiproliferative properties in vitro against hepatic carcinoma cells and several compounds were found to have good activities.

机译：介绍了2-氯喹啉-3-甲醛、丙二腈和1,3-二羰基化合物在微波辐照下高效合成新型官能化吡喃并[2,3-b]喹啉衍生物的方法。该协议具有效率高、反应条件温和、一锅程序、操作方便等优点。评估了所有这些化合物在体外对肝癌细胞的抗增殖特性，并发现几种化合物具有良好的活性。

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来源
《Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry》 |2018年第11期|1977-1990|共14页
作者
Lin Wei; Zhang Mengye; Wang NingXu WentaoShi Daqing;
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作者单位

Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Jiangsu, Peoples R China;

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正文语种英语
中图分类化学;
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AN EFFICIENT SYNTHESIS AND EVALUATION OF ANTITUMOR ACTIVITIES OF FUNCTIONALIZED PYRANO2,3-bQUINOLINES

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