Parkinson's disease (PD) is a neurodegenerative disease caused by the progressive loss of dopaminergic (DA) neurons in the midbrain projecting to the striatum, which leads to motor dysfunctions, such as bradykinesia (slowed movement), rigidity, and tremors. To replace the lost cells, the transplantation of DA neurons derived from embryonic stem cells or induced pluripotent stem cells (iPSCs) has been considered. In this issue of the JCI, Song et al. report on their development of an iPSC induction and differentiation protocol that can promote the realization of autologous transplantation to treat PD patients with their own cells.
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机译:帕金森病 (PD) 是一种神经退行性疾病,由投射到纹状体的中脑中多巴胺能 (DA) 神经元逐渐丧失引起,从而导致运动功能障碍,例如运动迟缓(运动迟缓)、僵硬和震颤。为了替换丢失的细胞,已经考虑移植来自胚胎干细胞或诱导多能干细胞 (iPSC) 的 DA 神经元。在本期JCI中,Song等人报告了他们开发的iPSC诱导和分化方案,该方案可以促进自体移植的实现,以用自己的细胞治疗PD患者。
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