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The effects of titanium nanoparticles on enzymatic and non-enzymatic biomarkers in female Wistar rats

机译:钛纳米颗粒对雌性Wistar大鼠酶促和非酶促生物标志物的影响

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摘要

Titanium dioxide (TiO2) nanoparticles (NPs) are widely used in industry, pharmacy, medicine, and food sectors. Therefore, this study deals with the effects of TiO2 NPs in female rats following oral administration in differing doses for 14 days (0, 0.5, 5, and 50mg/kg b.w./d). The response of enzymatic biomarkers (Na,K-ATPase, Mg-ATPase, and AChE) was measured in the brain, kidney, and small intestine, while non-enzymatic biomarker levels, such as different forms of glutathione (GSH) and thiobarbituric acid reactive substances (TBARSs) were measured in the liver. The images of the tissues were obtained using a transmission electron microscope (TEM) to demonstrate TiO2 NP accumulation. Data showed that brain AChE activity decreased at all TiO2 NP doses, though brain ATPase activities increased. However, ATPase activities in the intestine and kidney did not change significantly. Levels of GSH forms did not change significantly, though there was a significant decrease in TBARS level at the highest NP dose. TEM images demonstrated that TiO2 NPs accumulated in a dose-dependent manner in the tissues. Data emphasized that the brain was the most sensitive organ against the effects of TiO2 NPs. This study suggests the need for further studies to evaluate better the toxic effects of TiO2 NPs.
机译:二氧化钛 (TiO2) 纳米颗粒 (NP) 广泛应用于工业、制药、医药和食品领域。因此,本研究涉及 TiO2 NPs 对雌性大鼠以不同剂量口服 14 天(0、0.5、5 和 50mg/kg b.w./d)后的影响。在脑、肾和小肠中测量酶生物标志物(Na、K-ATP 酶、Mg-ATP 酶和 AChE)的反应,同时在肝脏中测量非酶生物标志物水平,例如不同形式的谷胱甘肽 (GSH) 和硫代巴比妥酸反应物质 (TBARS)。使用透射电子显微镜 (TEM) 获得组织图像以证明 TiO2 NP 积累。数据显示,尽管脑ATP酶活性增加,但所有TiO2 NP剂量的脑AChE活性都降低了。然而,肠道和肾脏中的ATP酶活性没有显着变化。GSH形式的水平没有显着变化,尽管在最高NP剂量下TBARS水平显着降低。透射电镜图像显示TiO2 NPs在组织中以剂量依赖性方式积累。数据强调,大脑是对TiO2 NPs影响最敏感的器官。这项研究表明需要进一步的研究来更好地评估TiO2 NPs的毒性作用。

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