miR-34c-5p and CaMKII are involved in aldosterone-induced fibrosis in kidney collecting duct cells

摘要

Mineralocorticoids trigger a profibrotic process in the kidney. In mouse cortical collecting duct cells, the present study addressed two main questions: 7) what are microRNAs (miRNAs) and their target genes that are changed by aldosterone? and 2) what do miRNAs, in response to aldosterone, regulate regarding signaling pathways related to fibrosis? A mi-croarray chip assay was done in cells in the absence or presence of aldosterone treatment