Perturbations of urea cycle enzymes during posthepatectomy rat liver failure

摘要

Posthepatectomy liver failure (PHLF) may occur after extended partial hepatectomy (PH). If malignancy is widespread in the liver, the size of PH and hence the size of the future liver remnant (FLR) may limit curability. We aimed to characterize differences in protein expression between different sizes of FLRs and identify proteins specific to the regenerative process of minimal-size FLR (MSFLR), with special focus on postoperative day (POD) / when PHLF is present. A total of 104 male Wistar rats were subjected to 30, 70, or 90 PH (MSFLR in rats), sham operation, or no operation.