Synthesis of Angularly Fused Aromatic Compounds from Alkenyl Enediynes by a Tandem Radical Cyclization Process

摘要

The synthetic potential of the Bergman cyclization (BC) has not been greatly explored despite remarkable progress in the understanding of the reaction mechanism and the mode of biological action of enediynes. The radicals within the 1,4-diradical generated during the BC are distally oriented, thus preventing self-quenching, which can lead to a highly strained bicyclo system, and are spin-paired by an external quencher.