Muscarinic suppression of ATP-sensitive K~+ channels mediated by the M_3/G_q/11/phospholipase C pathway contributes to mouse ileal smooth muscle contractions

摘要

ATP-sensi-tive K~+ (K_Atp) channels are expressed in gastrointestinal smooth muscles, and their activity is regulated by muscarinic receptor stimulation. However, the physiological significance and mechanisms of muscarinic regulation of Katp channels are not fully understood. We examined the effects of the Katp channel opener cromakalim and the Katp channel blocker glibenclamide on electrical activity of single mouse ileal myocytes and on mechanical activity in ileal segment preparations.