Potential antitumor agents. 37. Synthesis and antitumor activity of guanylhydrazones from imidazo2,1-bthiazoles and from the new heterocyclic system thiazolo2 ',3 ': 2,3imidazo 4,5-cquinoline

摘要

This paper reports synthesis and antitumor activity of new guanylhydrazones from imidazo2,1-bthiazoles and from the new heterocyclic system thiazolo2 ',3 ':2,3imidazo4,5-cquinoline. The compounds were tested as potential antitumor agents at the National Cancer Institute. The effect of the guanylhydrazone of 2-chloro-6-(2,5-dimethoxy-4-nitrophenyl)imidazo2,1-b-thiazole-5-carbaldehyde (41) was investigated, and it was found to be an inhibitor of Complex III of the mitochondrial respiratory chain and is able to induce apoptosis in the cell lines HT29 and HL60.