Synthesis and Biological Activity of 3,4-Diaryl-5-4-(acetylsulfamoyl)phenyl-4,5-dihydropyrrolo3,4-cpyrazol-6(2H)-ones and Their Sodium Salts

摘要

3,4-Diaryl-5-4-(acetylsulfamoyl)phenyl-4,5-dihydropyrrolo3,4-cpyrazol-6(2H)-ones were synthesized be reaction of 5-aryl-4-aroyl-1-4-(acetylsulfamoyl)phenyl-3-hydroxy-1H-pyrrole-2(5H)-ones with hydrazine hydrate in glacial acetic acid, and their sodium salts were obtained by treatment with sodium methoxide in methanol-DMF (1: 1). Analgesic and anti-inflammatory activity and acute toxicity of the synthesized compounds were studied.