A large animal model that recapitulates the spectrum of human intervertebral disc degeneration

Gullbrand S. E.; Malhotra N. R.; Schaer T. P.Zawacki Z.Martin J. T.Bendigo J. R.Milby A. H.Dodge G. R.Vresilovic E. J.Elliott D. M.Mauck R. L.Smith L. J.

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A large animal model that recapitulates the spectrum of human intervertebral disc degeneration

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Objective: The objective of this study was to establish a large animal model that recapitulates the spectrum of intervertebral disc degeneration that occurs in humans and which is suitable for pre-clinical evaluation of a wide range of experimental therapeutics.

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来源
《Osteoarthritis and cartilage》 |2017年第1期|146-156|共11页
作者
Gullbrand S. E.; Malhotra N. R.; Schaer T. P.Zawacki Z.Martin J. T.Bendigo J. R.Milby A. H.Dodge G. R.Vresilovic E. J.Elliott D. M.Mauck R. L.Smith L. J.;
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作者单位

Philadelphia VA Med Ctr, Translat Musculoskeletal Res Ctr, Philadelphia, PA USA;

Univ Penn, Dept Neurosurg, 424 Stemmler Hall,3450 Hamilton Walk, Philadelphia, PA 19104 USA;

Univ Penn, Sch Vet Med, Comparat Orthopaed Res Lab, Kennett Sq, PA 19348 USAUniv Penn, Dept Orthopaed Surg, McKay Orthopaed Res Lab, Philadelphia, PA USAPenn State Univ, Penn State Hershey Bone & Joint Inst, Hershey, PA USAUniv Delaware, Dept Biomed Engn, Newark, DE USA;

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正文语种英语
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
Goat; Caprine; Preclinical animal model; Disc degeneration; Chondroitinase ABC; Nucleotomy;

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A large animal model that recapitulates the spectrum of human intervertebral disc degeneration

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