GCSF Treatment for non-ischemic dilated cardiomyopathy. of Cardiovascular Pharmacotherapy

摘要

In 2001 research of endogenous cell therapy started. Or-lic et al. reported that granulocyte colony-stimulating factor (GCSF) and stem-cell-factor (SCF) improved heart function and the survival rate after myocardial infarction . They showed that the infarcted scar got smaller with newly-formed myocardium dramatically. Because they did not label bone marrow cells, it was not sure where the majority was originated from.To clarify this issue we tagged bone marrow cells with GFP for tracking . Survival rate was improved with GCSF. However, Bone marrow-derived myogenic cells were too small number to contribute to pump function directly.