The advent of combinatorial chemistry has led to an explosion of novel methods to prepare large libraries of compounds. While there have been numerous reviews and books published on the synthetic methodology needed to prepare diverse chemical structures, relatively little has been published on the equipment necessary to conduct combinatorial chemistry. Examination of the liteature on combinatorial chemistry indicates that there are numerous manufactures that supply reaction vessels suitable for the synthesis of chemicall libraries. These systems vary greatly in price and functionality; however, almost all of them utilize some type of reaction vessel, a method to mix reagents, and a method of heating or cooling these vessels. Refulxing in these reaction vessels is typically done using airflow around the headspce of the reaction vessel, although a few companies have instruments that have cooled condensers that can be added to the system.
展开▼
