Rheumatoid arthritis (RA)-associated interstitial lung disease (RA-ILD) develops in -20 of patients with RA. SKG mice, which are genetically prone to development of autoimmune arthritis, develop a pulmonary interstitial pneumonia that resembles human cellular and fibrotic nonspecific interstitial pneumonia. Nintedanib, a tyrosine kinase inhibitor approved for treatment of idiopathic pulmonary fibrosis, has been shown to reduce the decline in lung function.
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机译：类风湿性关节炎 （RA） 相关间质性肺病 （RA-ILD） 发生于 -20% 的 RA 患者。SKG小鼠在遗传上容易发生自身免疫性关节炎，其发展为类似于人类细胞和纤维化非特异性间质性肺炎的肺间质性肺炎。尼达尼布是一种酪氨酸激酶抑制剂，被批准用于治疗特发性肺纤维化，已被证明可以减少肺功能的下降。
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