Design, synthesis and pharmacological analysis of 5-4 '-(substituted-methyl)1,1 '-biphenyl-2-yl-1H-tetrazoles

摘要

In the present paper 5-4'-({4-(4-aryloxy)methyl-1H-1,2,3-triazol-1-yl}methyl)1,1'-biphenyl-2-yl-1H-tetrazoles (5a-g) and 2'-(1H-tetrazol-5-yl)1,1'-biphenyl-4-ylmethyl-substituted-1-carbodithioates (11h-q) have been designed and synthesized. These compounds were subjected to docking (against AT(1) receptor protein enzyme in complex with Lisinopril), in vitro angiotensin converting enzyme inhibition, anti-proliferative, anti-inflammatory screening (through egg albumin denaturation inhibition and red blood cell membrane stabilization assay) and finally anti-fungal activity analyses. Some of the compounds have shown significant pharmacological properties.