Few landmark drugs in this series have so dramatically changed the way that a disease is managed as the first antipsychotic agent chlorpromazine. From the day in January 1952 that it was used to calm a young, severely agitated male patient in a Paris hospital, contributing to his release 20 days later,' interest in chlorpromazine spread rapidly through Europe and North America. In less than a year, it was available on prescription in France as Largactil - a brand name reflecting its "large action."
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