Background:The ventilation ( ) response to inspired CO2 has been extensively studied, but rarely with concentrations >10.Aims:These experiments were performed to determine whether would increase correspondingly to higher concentrations and according to conventional chemoreceptor time delays.Materials and Methods:We exposed anesthetized dogs acutely, with and without vagotomy and electrical stimulation of the right vagus, to 20-100 CO2-balance O2 and to 0 and 10 O2-balance N2.Results:The time delays decreased and response magnitude increased with increasing concentrations (p<0.01), but at higher concentrations the time delays were shorter than expected, i.e., 0.5 s to double at 100 CO2, with the response to 0 O2 being ~3 s slower. Right vagotomy significantly reduced baseline breathing frequency (fR), increased tidal volume (VT) and increased the time delay by ~3 s. Bilateral vagotomy further reduced baseline fR and , and reduced the response to CO2 and increased the time delay by ~12 s. Electro-stimulation of the peripheral right vagus while inspiring CO2 caused a 13 s asystole and further reduced and delayed the response, especially after bilateral vagotomy, shifting the mode from VT to fR.Conclusions:Results indicate that airway or lung receptors responded to the rapid increase in lung H+ and that vagal afferents and unimpaired circulation seem necessary for the initial rapid response to high CO2 concentrations by receptors upstream from the aortic bodies.
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