Palladium(0)-Catalyzed Intermolecular Allylic Dearomatization of Indoles by a Formal 4+2 Cycloaddition Reaction

摘要

Bridged indoline derivatives were synthesized by an intermolecular Pd-catalyzed allylic dearomatization reaction of substituted indoles. The reaction between indoles and allyl carbonates bearing a nucleophilic alcohol side-chain proceeds in a cascade fashion, providing bridged indolines in excellent enantioselectivity.