CYTOTOXICITY STUDIES OF TETRAPRELYLTOLUQUINONE, A PRENILATED HYDROQUINONE FROM GARCINA COWA ROXB ON H-460, MCF-7 AND DU-145

摘要

Objective: The aim of the present study was to examine the cytotoxicity of a new ring-reduced tetra prenyltoluquinone (TPTQ), 2 E ,6 E ,10 E -(+)-4b-hydroxy-3-methyl-5b-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl-2-cyclohexen-1-one against H-460, MCF-7 and DU-145 cell lines. Methods : Different concentrations of TPTQ were subjected to cytotoxicity study by using MTT method and calculate the percentage of cell viability. Results : The results of this study showed that this compound has IC 50 value 16.3 ± 3.0 µM in H-460 cancer cell lines without any activities towards another two type of cell lines. Conclusion : TPTQ had selective activity against H-460 cancer cell lines. Keywords: Garcinia cowa , TPTQ, H-460, MCF-7, DU-145, Cell viability, Cytotoxicity.