IBIS(TRIFLUOROACETOXY)IODOp-NITROBENZENE AND BIS(TRIFLUOROACETOXY)IODOPENTAFLUOROBENZENE AS LEAD REAGENTS FOR THE DIRECT RING CONTRACTION OF LACTAMS TO PYRROLIDINES

摘要

Two lambda(3)-iodanes, namely bis(trifluoroacetoxy)iodop-nitrobenzene and bis(trifluoroacetoxy)iodopentafluorobenzene, were used to effect the direct ring-contraction of lactams to pyrrolidines. Intense reaction optimization was necessary but only alpha,alpha-disubstituted lactams succumbed to our efforts thus far.