Transformations of alkyl (5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)acetates into 5-heteroaryl-3-oxo-2-phenyl-3,5-dihydro-2H-pyrazolo4,3-cpyridine-7-carboxylates

摘要

Alkyl (Z)-4-dimethylaminomethylidene-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-3-ylacetate (4) was transformed with N- and C-nucleophiles into alkyl 4-(subsituted amino)methylidene-4,5-dihydro-1H-pyrazol-3-ylacetates (7) and alkyl (4-heteroarylmethylidene-4,5-dihydro-1H-pyrazol-3-yl)acetates (8),respectively.Compounds (7) cyclize by heating with DMFDMA in DMF into 2H-pyrazolo4,3-cpyridine-7-carboxylates (9).