Nitrofurantoin and Renal Function: Does Evidence Support the Creatinine Clearance Cutoff?

摘要

In our previous column,we discussed the importance of properly estimating renal function when determining medication dosing, particularly in elderly patients. This column will focus on the clinical application of that renal function estimation in a common clinical scenario: the use of nitrofurantoin for the treatment of a urinary tract infection (UTI). Let's start by revisiting our case.