A FACILE SYNTHESIS OF NOVEL PYRIDO2 ',1 ':2,3IMIDAZO4,5-c-beta-CARBOLINES

摘要

An efficient tandem process for the synthesis of pyridoimidazo-fused beta-carbolines: pyrido2",1":2'3' imidazo 4',5':2,3pyrido4,5-bindole, is described. The construction of these compounds was achieved by one-pot three component reaction of 1-benzy1-1H-indole-3-carbaldehyde, 2-aminopyridine and trimethylsilyl cyanide via Groebke-Blackburn-Bienayme reaction, followed by cyclization through the Pictet-Spengler reaction of the resulting imidazo1,2-apyridine which allowed access to the title heterocycles.