SYNTHESIS OF 6,7-DIHYDRO-9,10-DIMETHOXYDIBENZOa,fQUINO-LIZINIUM SALT AND ITS D-RING SUBSTITUTED DERIVATIVES

摘要

Synthesis of 6,7-dihydro-9,10-dimethoxydibenzoa,fquinolizinium salt (2a) and its derivatives (2b-g) substituted at the D ring has been achieved from 3-(2-bromoaryl)propanoic acid (3) in four steps for future examination of the inhibitory activity of these compounds against topoisomerase. The dihydrocarbostyrils (5a-g), key intermediates in this synthetic scheme, were prepared from the amides (4a-g) via intramolecular aryl amidation reactions.