Editorial Comment on: Surveillance Study in Europe and Brazil on Clinical Aspects and Antimicrobial Resistance Epidemiology in Females with Cystitis (ARESC): Implications for Empiric Therapy

摘要

An alarming trend of resistance development among common pathogens has been observed worldwide . This changing pattern is directly linked to the use of antimicrobial agents . Also, there is a lack of development of new antibiotics by the drug industry, and the research on alternative preventive and therapeutic approaches is still at an experimental level. Warning signals are coming from experts that we might soon be disarmed against life-threatening infections and even have difficulty treating uncomplicated infections.From this perspective, the article by Naber et al published in this issue of European Urology is an important contribution to the understanding of global resistance patterns . By analysing the variation of bacterial susceptibility in females with cystitis in nine European countries and Brazil and using one standard protocol and laboratory performance, the authors confirm a pessimistic trend. They find the resistance of E. coli to ciprofloxacin reaches 11.7% in Italy and 12.9% in Russia and resistance to co-trimoxazole reaches more than 40% in Hungary. These figures are highly alarming because they represent standard, community-acquired strains. The study is in line with other global projects studying bacterial susceptibility in urologic units that show resistance to F-quinolones ranging from 14% to 81% .