The pathophysiological mechanisms of cognitive and behavioral disturbances in children with Landau-Kieffner syndrome or epilepsy with continuous spike-and-waves during slow-wave steep

摘要

Epilepsy with continuous spike- and -waves during slow-wave steep and Landau-Kleffner syndrome are two rare childhood epilepsy syndromes. The underlying pathophysiology remains unknown. The current opinions about epidemiologic risk factors, genetic predisposition, EEG and MEG findings, influence of anti-epileptic drugs, neuroradiology, positron emission tomopgraphy, evoked potentials, autoimmunity and subpial transection are summarized. (C) 2006 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.