THE REACTIVITY OF 4 '-SUBSTITUTED SPIROISOINDOLE-1,3 '-PYRAZOLES DERIVATIVES: SUBSTITUTION/ELIMINATION REACTIONS AND ACCESS TO BIARYL DERIVATIVES

摘要

This paper describes aspects of the chemistry of 4'-substituted spiroisoindole-1,3'-pyrazoles. These compounds underwent substitution and/or elimination reactions to afford some new spiro- as well as biaryl derivatives of potential pharmaceutical relevance. Mechanistic considerations are discussed as well.