SYNTHESIS OF 12,12a-DIHYDRO-7,12a-DIAZACYCLOHEPTAcd-BENZgAZULEN-12-ONE (CYCLOHEPTAmnPYRROLO2,1-c1,4-BENZODIAZEPIN-12-ONE) AND EVALUATION OF CYTOTOXIC ACTIVITY AGAINST HeLa S3 CELLS

Eiko Yoshioka; Hiroyuki Fujii; Toshihiro Murafuji

首页> 外文期刊>Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry >SYNTHESIS OF 12,12a-DIHYDRO-7,12a-DIAZACYCLOHEPTAcd-BENZgAZULEN-12-ONE (CYCLOHEPTAmnPYRROLO2,1-c1,4-BENZODIAZEPIN-12-ONE) AND EVALUATION OF CYTOTOXIC ACTIVITY AGAINST HeLa S3 CELLS

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SYNTHESIS OF 12,12a-DIHYDRO-7,12a-DIAZACYCLOHEPTAcd-BENZgAZULEN-12-ONE (CYCLOHEPTAmnPYRROLO2,1-c1,4-BENZODIAZEPIN-12-ONE) AND EVALUATION OF CYTOTOXIC ACTIVITY AGAINST HeLa S3 CELLS

机译：12,12a-二氢-7,12a-二氮杂环庚烷cd-苯并g氮杂-12-酮（环庚烷MN吡咯并2,1-c1,4-苯并二氮杂卓-12-酮）的合成及对HeLa S3细胞的细胞毒性活性评估

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摘要

12,12a-dihydro-7,12a-diazacycloheptacdbenzgazulen-12-one (cycloheptamnpyrrolo2,1-c1,4benzodiazepin-12-one) derivative (7) was synthesized by the intramolecular cyclization of methyl 2-(3-phenyl-1-azaazulen-8-yl)aminobenzoate. Compound (7) showed extremely strong cytotoxic activity against HeLa S3 cells (IC_(50)=0.543 ± 0.063 μM).

机译：12,12a-二氢-7,12a-二氮杂环庚烷[cd]苯并[g]氮杂-12-酮（环庚烷并[mn]吡咯并[2,1-c][1,4]苯并二氮杂杂卓-12-酮）衍生物（7）由2-（3-苯基-1-氮杂呋喃-8-基）氨基苯甲酸甲酯分子内环化合成。化合物（7）对 HeLa S3 细胞具有极强的细胞毒性活性（IC_（50）=0.543 ± 0.063 μM）。

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来源
《Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry》 |2011年第6期|1409-1415|共7页
作者
Eiko Yoshioka; Hiroyuki Fujii; Toshihiro Murafuji;
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作者单位

Science Research Center, Yamaguchi University, Yoshida, Yamaguchi 753-8512, Japan;

Graduate School of Medicine, Yamaguchi University, Yoshida, Yamaguchi 753-8512, Japan;

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SYNTHESIS OF 12,12a-DIHYDRO-7,12a-DIAZACYCLOHEPTAcd-BENZgAZULEN-12-ONE (CYCLOHEPTAmnPYRROLO2,1-c1,4-BENZODIAZEPIN-12-ONE) AND EVALUATION OF CYTOTOXIC ACTIVITY AGAINST HeLa S3 CELLS

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