Synthesis of 9-aryl-6-(4-trifluoromethylpheny1)-1,2,4-triazolo4,3-a 1,8naphthyridines using Cu(OAc)(2) under microwave irradiation and their antibacterial activity

摘要

An effective, practical and simple approach towards the synthesis of 9-aryl-6-(4-trifluoromethylphenyl)-1,2,4-triazolo 4,3-a-1,8naphthyridines 8 from the corresponding aryl aldehyde 3-(4-trifluoromethylpheny1)-1,8-naphthyridin-2-ylhydrazones 7 has been achieved, using Cu(OAc)(2) in combination with microwave irradiation. The products are obtained in good yields and in a state of high purity. The structural assignments of compounds 3-8 are based on their elemental analyses and spectral (IR, H-1 NMR and mass spectroscopy) data. The compounds 8 have been screened for their antibacterial activity.