Lytic bone lesions and hypercalcemia are common features of multiple myeloma. In contrast, they are exceptional in other B-cell malignancies. Myeloma bone involvement is related to an uncoupling process associating increased osteoclastic resorption with decreased bone formation. Several osteoclast-activating factors, such as interleukin-1, macrophage colony-stimulating factor, and interleukin-6, are involved in this process. However, interleukin-6, the major myeloma cell growth factor, plays a critical role in myeloma-induced bone resorption.
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机译:溶骨性病变和高钙血症是多发性骨髓瘤的常见特征。相比之下,它们在其他 B 细胞恶性肿瘤中是例外的。骨髓瘤骨受累与脱钩过程有关,该过程将破骨细胞吸收增加与骨形成减少相关联。几种破骨细胞激活因子,如白细胞介素-1、巨噬细胞集落刺激因子和白细胞介素-6,都参与这一过程。然而,白细胞介素-6 是主要的骨髓瘤细胞生长因子,在骨髓瘤诱导的骨吸收中起着关键作用。
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