Sugar-modified B-cell receptors in DLBCL

摘要

In this issue of Blood, Chiodin et al1 show that diffuse large B-cell lymphomas (DLBCLs) of a particular subgroup frequently acquire N-glycosylation sites in their B-cell receptor (BCR) genes and carry oligomannose-type glycans that promote BCR signaling, most likely by binding to lectins in the lymphoma microenvironment.