A convenient method for the preparation of 4-amino-6-aryl-6H-pyrrolo1,2-a1benzazepine-5-carbonitriles has been developed. The method is based on the hydrogen bromide-mediated cyclization reaction of 2-{aryl2-(1H-pyrrol-1-yl)phenylmethyl}propanedinitriles, produced by the treatment of 2-(1H-pyrrol-1-yl)phenyllithiums with arylidenemalononitriles. The lithium compounds can be easily generated by the bromine/lithium exchange between 1-(2-bromophenyl)-1H-pyrroles and butyllithium.
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