FORMATION OF THE 1H-PYRROLO3,4-cPYRIDIN-1-ONE SKELETON VIA INTRAMOLECULAR DIELS-ALDER REACTION OF OXAZOLES

摘要

The 1H-pyrrolo3,4-cpyridin-1-one derivatives (4a-c) were prepared through a route employing the intramolecular Diels-Alder reaction of the oxazole-olefins (3a-c). Conversion of the crotonamide (3a) into 4a was effectively promoted by the addition of Cu(OTf)2 as a catalyst.