Protective Effect of Ketotifen and Disodium Cromoglycate Against Bronchoconstriction Induced by Aspirin, Benzoic Acid or Tartrazine in Intolerant Asthmatics

摘要

Oral challenge tests with acetylsalicylic acid, tartrazine or benzoic acid were performed in 7 intolerant asthmatic patients after a 3-day treatment with either orally taken ketotifen (1 mg twice daily) or inhaled disodium cromoglycate (20 mg four times daily) at random. Protection was noted with ketotifen in 5, with DSCG in 3 patients. On the evaluation of the mean percentage of the maximum decline in the forced expiratory volume in 1 sec (FEV1 only ketotifen afforded significant protection statistically (p α1-antitrypsin serum values were under the lower normal range