Resistance to thyroid hormone (RTH) is characterized by reduced sensitivity to thyroid hormone, mostly caused by mutation in the thyroid hormone receptor fi (TRft) gene. Patients with RTH have increased free triiodothyroxine (FT3) and free thyroxine (FT4) and unsuppressed thyrot-ropin (TSH) levels 1. Here, we describe a rare case of RTH coexisting with Graves' disease (GD).A 17-year-old man presented to the hospital because of fatigue, palpitation, hand tremors, weight loss (6 kg), and a large goiter. His blood pressure and heart rate were 127/76 mmHg and 102 beats/min, respectively. He had no growth or mental retardation. Serum TSH, FT3, and FT4 levels were <0.05 LiU/ml (reference 0.541-4.261), 24.5 pg/ml (reference 2.39-4.06), and 6.46 ng/dl (reference 0.71-1.52), respectively.
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