20 patients with various forms of evolutive, colliguative tuberculous lesions of the bones and joints were treated with Rifampicin (RMP) administered systemically and locally (intra-focal injection). Blood, urine and pus samples were taken 3, 6,9, 12 and 24 h after systemic administration and at the same intervals and, in addition, 48 and 72 h after local administration; microbiological and spectrophotometric methods were used for the assay. Good diffusibility was noted at the focus level after systemic treatment only in recent and not in long-standing cases, which need additional local treatment. In the latter condition the drug persists a long time (7 and even 30 days in 1 case) after local administration. Indications for RMP therapy on the basis of these data are discussed.
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