In this issue of epigenetics

摘要

It is now well established that most pre-mRNA processing events (including capping, splicing, cleavage and polyade-nylation) are coupled with transcription. For example, variations in transcription can influence the outcome of alternative processing events. Recent data now point toward a connection between chromatin structure and the splicing process. In this issue of Epigenetics, two enlightening Point of View articles by Schor el al. and Tilgner and Guigo review the current understanding of the mechanisms by which intragenic chromatin modifications regulate alternative splicing.