The problem of a combination of diseases is of great in the clinical treatment of internal diseases. Syntropy is of great significance to the northern population. A total of 617 patients living in Yakutia were studied. Analysing the combination of chronic pathology by means of the international classification of diseases was revealed that 7.4 of patients have only one nosological form and 55.1 had been diagnosed with 5 and more nosologies. When analysing the combination of the classes of the international classification of diseases it was seen that patients with one class constituted 14.0. At same time the number of classes of the diagnosed pathology comprised 3 and more in 44.3 of the patients. In our opinion the process of long human adaptation to severe climatic conditions leads to a decrease of the functional reserves in an organism and disadaptation in newcomers. It leads to the development of severe chronic polynosological pathology, pathogenesis of which is defined by the for need complex of disadaptive disorder.
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