Platelet-derived growth factor-o receptor is required for CMV infection

摘要

Human cytomegalovirus (HCMV) infection is widespread (in 50-80 of seropositive individuals), but the virus can be an important pathogen in immunocompromised individuals. Despite antiviral drugs and prophylactic maneuvers. Upon attachment to the cell, the virus induces a potent cellular interferon-like response, which activates downstream growth factor-like receptor tyrosine kinase (RTK) and integrin signaling pathways. However, the mechanisms facilitating viral entry and gene expression are not clearly understood. In a recent communication, Soroceanu et al. reported that the platelet-derived growth factor-a receptor (PDGFR-a) is needed for viral entry into the cell and subsequent gene expression. They found that PDGFR-a was phosphorylated by both laboratory and clinical isolates of HCMV in various human cell types (Figure), resulting in activation of the phosphoinositide-3-kinase signaling pathway.