Prostaglandin E2 and IL-23 interconnects STAT3 and RoR gamma pathways to initiate Th17 CD4(+) T-cell development during rheumatoid arthritis

摘要

The chronic inflammation associated with rheumatoid arthritis (RA) leads to focal and systemic bone erosion of the joints resulting in a crippling disability. Recent reports indicate an increase in the incidence of RA in the coming years, placing a significant burden on healthcare resources. The incidence of RA is observed to be increasing with age and a significant proportion of those new cases will be aggressively erosive.