Metal-Free Synthesis of Coumarin-fused Pyrimidines from 4-Aminocoumarins via Pseudo Four-component Reaction

摘要

abstract_textpAn efficient pseudo four-component procedure for the construction of chromeno4,3-dpyrimidin-5-ones, a type of coumarin-fused pyrimidines, from 4-aminocoumarins, two molecules of aromatic aldehydes and ammonium iodide under metal-free conditions is developed. The coumarin-pyrimidine hybrids readily undergo sequential hydrolysis and alkylation to give all-carbon substituted pyrimidines in excellent yields. One-pot synthesis of pyrimidines from readily available 4-aminocoumarins and other commodity chemicals is exemplified./p/abstract_text