Abstract To investigate the effects of genetic and non-genetic factors on bone mineral densities (BMDs) and osteoporotic fractures. This was a cross-sectional study to investigate the relationships between 18 SNPs and non-genetic factors with BMDs and osteoporotic fractures in 1012 Chinese Han women. Five SNPs in genes GPR177, CTNNB1, MEF2C, SOX6, and TNFRSF11B were associated with LI-4 or total hip BMDs. rsl 1898505 in SPTBN1 gene was associated with osteoporotic fractures. Subjects carrying the largest number of risk alleles (highest 10 ) not only had lower BMD values as compared to those carrying the least number of risk alleles (lowest 10 ), they also had a higher risk of fracture P - 0.002, OR = 2.252, 95 CI (1.136, 4.463). Results from multi-variate stepwise regression analysis revealed that age P < 0.001, OR = 1.038, 95 CI (1.018, 1.058), number of falls in a year P < 0.001, OR = 2.347, 95 CI (1.459, 3.774), the G risk allele in rsl 1898505 P = 0.023, OR = 1.559, 95 CI (1.062, 2.290), and the Ll-4 BMD P = 0.017, OR = 0.286, 95 CI (0.102, 0.798) were associated with the occurrence of osteoporotic fractures. Genetic (rsl 1898505) and non-genetic factors (age, number of falls in a year and Ll-4 BMD) could work in concert to contribute to the risk of osteoporotic fractures.
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