Rhodium-Catalyzed Direct Bis-cyanation of Arylimidazo1,2-alphapyridine via Double C-H Activation

摘要

An efficient Cp*Rh(III)-catalyzed selective bis-cyanation of arylimidazo1,2-alphapyridines with N-cyano-N-phenylp-methylbenzenesulfonamide via N-directed ortho double C-H activation has been developed. The reaction proceeds with broad functional group tolerance to furnish various cyanated iinidazopyridines in high yields. The current methodology exhibits unique characteristics, including high bis-cyanation selectivity, operational convenience, and gram-scale production.