An Eco-Sustainable Synthetic Approach for 4,5-Dihydro-1H-pyrazoles via DBU Catalysis in Micellar Medium

摘要

abstract_textpAn efficient and straightforward synthetic strategy for pharmaceutically pertinent scaffold 4,5-dihydro-1H-pyrazole has been reported initiating from highly substituted chalcones (1) and thiosemicarbazide (2) as reactants in an aqueous micellar medium by the use of DBU (1,8-Diazabicyclo5.4.0undec-7-ene) as an organobase. The use of CTAB (Cetyl Trimethyl Ammonium Bromide) as a surfactant, which forms a colloidal dispersion with organic substrates with the enhancement of the reactivity of substrates is the key feature of this technique. Organic synthesis in aqueous micellar medium, use of organocatalyst DBU, mild reaction conditions, sustainable synthesis, experimental feasibility, broad substrate scope, short reaction time and high yields are some other attributes of this protocol./p/abstract_text