Rhodium-Catalyzed ortho-Selective C-F Activation and Hydrodefluorination of Heterocycle-Substituted Polyfluoroarenes: Dominated by Phosphine Ligands

摘要

abstract_textpIn this paper, the ortho-selective mono-hydrodefluorination and/or di-hydrodefluorination of heterocycle substituted poly-fluoroarenes were catalyzed by rhodium complexes along with phosphine ligands and ethanol as hydride source. Diverse partially fluorinated aromatics had been synthesized by this method. The study of the mechanism demonstrated that ethanol was the sole hydride source in the cycle of hydro-defluorination. Furthermore, the phosphine ligand controlled chemoselectivity had been discussed by monitoring experiment./p/abstract_text