Environmentally Benign Copper Triflate-Mediated Multicomponent One-Pot Synthesis of Novel Benzogchromenes Possess Potent Anticancer Activity

摘要

abstract_textpAn efficient multi-component one-pot synthesis of highly functionalized 5,10-dihydro-4H-benzog chromenes-3-caronitrile derivatives from 2-hydroxy-1,4-naphthoquinone, aromatic aldehyde and malonitrile in the presence of Cu(OTf) 2 catalyst and eco friendly polyethylene glycol solvent was carried out under ultrasonication. The reaction was completed within 10 minutes and resulted in good yield. The synthesized com-pounds were tested for their in-vitro anticancer activity against cervical cancer cell line (HeLa). Nine out of ten compounds showed potent antitumor activity better than that of doxorubicin. 2-Amino-4-(3-methoxy-2-hydroxy)-5,10-dioxo-5,10-dihydro- 4H-benzog chromene-3-carbonitrile displayed highest activity among the test compounds and doxorubicin with IC50 equal to 1.27 mu M./p/abstract_text