Regulation of Fn14 stability by scF~Fbxw7alpha during septic acute kidney injury

摘要

Acute kidney injury (AKI) initiated by sepsis remains a thorny problem despite recent advancements in its clinical management. Having been found to be activated during AKI, fibro-blast growth factor-inducible molecule 14 (Fnl4) may be a potential therapeutic target because of its involvement in the molecular basis of injury. Here, we report that LPS induces apoptosis of mouse cortical tubule cells mediated by Fn14, for which simultaneous Toll-like receptor (TLR)4 activation is required.