An Efficient Ecofriendly Enantioselective Organocatalytic Ring-Closing Reaction of 2-Hydroxychalcone via Intramolecular Oxa-Michael Reaction

摘要

An organocatalyzed highly asymmetric cascade oxa-Michael addition reaction for the synthesis of flavanone from 2-hydroxychalcone has been developed. This method works well with low catalyst loading and has broad range substrate scope, furnishing the desired product in excellent yield and displays an intrinsic enantioselectivity of upto 99.9 ee. This method provides a straightforward entry into highly functionalized chiral flavanone derivatives.