A One-pot Facile Construction of 1H-1,2,3-Triazolyl 1,2-Dihydropyridyl Derivatives and Evaluation of Bioactivity Profile

摘要

abstract_textpA one-pot, facile method has been established for the preparation of 1H-1,2,3-triazolyl 1,2-dihydropyridyl derivatives 6 a-y. The ring opening of the chromone and cyclo addition are the notable reactions to achieve the target compounds 6 a-y. All the compounds were screened for their antiproliferative, free radical scavenging (DPPH, ABTS(.+)), alpha-glucosidase inhibitory and anti-inflammatory activities. The bioactivity profile revealed that the compounds 6 x-y were shown potent antiproliferative activity against HeLa cell line, while compounds 6 e-h and 6 w identified as potent ABTS(+.) and 6 n identified as potent DPPH free radical scavenger. Compounds 6 h-i, 6 p-r, 6 u and 6 w denoted promising anti-inflammatory activity./p/abstract_text