Design, Docking, and Synthesis of Quinoline-2H-1,2,4-triazol-3(4H)-ones as Potent Anticancer and Antitubercular Agents

摘要

abstract_textpA new series quinoline-2H-1,2,4-triazol-3(4H)-ones 7 g-n and 11 g-n were designed and synthesized. Docking studies of title compounds with DNA (PDB: 1AU5) and with long-chain enoyl-acyl carrier protein reductase (InhA) enzyme (PDB ID: 4TZK) as anticancer and antitubercular targets showed good insights on the possible interactions. Further, the compounds were tested for in vitro anticancer activity against HeLa human cervix tumor cell line and also in vitro antitubercular activity against M. tuberculosis H37Rv MTB (ATCC-27294). Some of the compounds exhibited promising activities in both the protocols. Hence, these compounds may be considered as pharmacological lead molecules of interest./p/abstract_text