A Facile Synthesis and Antituberculosis Properties of Almazole D and Its Enantiomer

摘要

abstract_textpAn efficient route for the synthesis of almazole D has been developed using oxidative cyclization as a key step. This approach is successfully applied to the first synthesis of almazole D enantiomer. (R)-almazole D and synthesized intermediates showed potent inhibition of Mycobacterium tuberculosis. This hybrid 5-(3-indolyl) oxazole scaffold has drug like properties and is a good starting point for further exploration in antituberculosis drug discovery./p/abstract_text